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It inhibits the CYP3A enzyme-mediated hepatic metabolism of lopinavir, resulting in an increased plasma concentration of lopinavir.
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Use of the drug Kaletra once a day in children under 18 years of age.
800/200 mg (4 tablets) once a day in patients with no more than two mutations associated with the development of resistance to lopinavir. There are insufficient data for the use of Kaletra once daily in patients with more than two mutations associated with the development of resistance to lopinavir. |